Engineering a targeted delivery platform using Centyrins

Nanogels as a Chemically Controllable Platform for Targeted Drug Delivery

Targeted nanogels: a versatile platform for drug delivery to tumors.

Although nanoparticle-based drug delivery formulations can improve the effectiveness and safety of certain anticancer drugs, many drugs, due to their chemical composition, are unsuitable for nanoparticle loading. Here, we describe a targeted nanogel drug delivery platform that can (i) encapsulate a wide range of drug chemotypes, including biological, small molecule, and cytotoxic agents; (ii) d...

A cooperative polymeric platform for tumor-targeted drug delivery.

In the pursuit of effective treatments for cancer, an emerging strategy is "active targeting", where nanoparticles are decorated with targeting ligands able to recognize and bind specific receptors overexpressed by tumor cells or tumor vasculature so that a greater fraction of the administered drugs are selectively trafficked to tumor sites. However, the implementation of this strategy has face...

Metabolic engineering of a tyrosine-overproducing yeast platform using targeted metabolomics

BACKGROUND L-tyrosine is a common precursor for a wide range of valuable secondary metabolites, including benzylisoquinoline alkaloids (BIAs) and many polyketides. An industrially tractable yeast strain optimized for production of L-tyrosine could serve as a platform for the development of BIA and polyketide cell factories. This study applied a targeted metabolomics approach to evaluate metabol...

Advances in Targeted Drug Delivery